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Article

Integrating the Alzheimer's Disease Proteome and Transcriptome: A Comprehensive Network Model of a Complex Disease

1 Feb 2012

Abstract excerpt

Network models combined with gene expression studies have become useful tools for studying complex diseases like Alzheimer's disease. We constructed a "Core" Alzheimer's disease protein interaction network by human curation of the primary literature. The Core network consisted of 775 nodes and 2,204 interactions. To our knowledge, this is the most comprehensive and accurate protein interaction network yet...

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PMID: 22321014
DOI: 10.1089/omi.2011.0054

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