Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.

doi:10.1016/j.canlet.2017.09.013

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Article

Activation of SRY accounts for male-specific hepatocarcinogenesis: Implication in gender disparity of hepatocellular carcinoma.

Cancer letters - 1 Dec 2017

Liu Chang, Ren Yi-Fan, Dong Jian, Ke Meng-Yun, Ma Feng, Monga Satdarshan P S, Wu Rongqian, Lv Yi, Zhang Xu-Feng

Abstract excerpt

Sex affects the risk, treatment responses and outcome of many types of cancers. The mechanism of gender disparity in development of hepatocellular carcinoma (HCC) remains obscure. Sex-determining region on Y chromosome (SRY) was overexpressed in approximate 84% male patient HCC. Moreover, we are the first to generate a liver-specific transgenic (TG) murine model with overexpression of the male specific gene SRY....

Topics

Animals
Carcinoma, Hepatocellular
Cell Transformation, Neoplastic
Cyclin D1
Diethylnitrosamine
Female
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Health Status Disparities
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver Neoplasms

Male

Mice, Inbred C57BL

Mice, Transgenic

Phenotype

Phosphatidylinositol 3-Kinase

Proto-Oncogene Proteins c-akt

Proto-Oncogene Proteins c-myc

Source

Open in PubMed

Identifiers

PMID: 28942012
DOI: 10.1016/j.canlet.2017.09.013

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