Article
The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.
Genes, brain, and behavior - 1 Jun 2013
Sorge R E, LaCroix-Fralish M L, Tuttle A H, Khoutorsky A, Sotocinal S G, Austin J-S, Melmed K, Labialle S, Schmidt J V, Wood J N, Naumova A K, Mogil J S
Abstract excerpt
We recently observed a reliable phenotypic difference in the inflammatory pain sensitivity of a congenic mouse strain compared to its background strain. By constructing and testing subcongenic strains combined with gene-expression assays, we provide evidence for the candidacy of the Yy1 gene - encoding the ubiquitously expressed and multifunctional Yin Yang 1 transcription factor - as responsible. To confirm this...
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