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Article

The magnitude of hedgehog signaling activity defines skin tumor phenotype.

The EMBO journal - 2 Jun 2003

Grachtchouk Vladimir, Grachtchouk Marina, Lowe Lori, Johnson Tim, Wei Lebing, Wang Aiqin, de Sauvage Fred, Dlugosz Andrzej A

Abstract excerpt

Gain-of-function mutations in SMO have been implicated in constitutive activation of the hedgehog signaling pathway in human basal cell carcinomas (BCCs). We used a truncated keratin 5 (DeltaK5) promoter to assess the potential role of the human M2SMO mutant in BCC development in adult transgenic...

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Source

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Identifiers

PMID: 12773389
DOI: 10.1093/emboj/cdg271
PMCID: PMC156767

Genes

SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12773389-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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