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Article

The binding orientations of structurally-related ligands can differ; A cautionary note.

Neuropharmacology - 1 Jun 2017

Ruepp Marc-David, Wei Hao, Leuenberger Michele, Lochner Martin, Thompson Andrew J

Abstract excerpt

Crystal structures can identify ligand-receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5-HT3 and α7 nACh receptors and its binding orientation has been determined in the structural homologue AChBP (pdbid: 2WNC). Co-crystallisation with a structurally-related...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28137449
DOI: 10.1016/j.neuropharm.2017.01.023
PMCID: PMC5464333

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