Article
Genomic characterization of a large panel of patient-derived hepatocellular carcinoma xenograft tumor models for preclinical development.
Oncotarget - 21 Aug 2015
Gu Qingyang, Zhang Bin, Sun Hongye, Xu Qiang, Tan Yexiong, Wang Guan, Luo Qin, Xu Weiguo, Yang Shuqun, Li Jian, Fu Jing, Chen Lei, Yuan Shengxian, Liang Guibai, Ji Qunsheng, Chen Shu-Hui, Chan Chi-Chung, Zhou Weiping, Xu Xiaowei, Wang Hongyang, Fang Douglas D
Abstract excerpt
Lack of clinically relevant tumor models dramatically hampers development of effective therapies for hepatocellular carcinoma (HCC). Establishment of patient-derived xenograft (PDX) models that faithfully recapitulate the genetic and phenotypic features of HCC becomes important. In this study, we first established a cohort of 65 stable PDX models of HCC from corresponding Chinese patients. Then we showed that the...
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