Article
Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.
Proceedings of the National Academy of Sciences of the United States of America - 17 Dec 2019
Patro Sean C, Brandt Leah D, Bale Michael J, Halvas Elias K, Joseph Kevin W, Shao Wei, Wu Xiaolin, Guo Shuang, Murrell Ben, Wiegand Ann, Spindler Jonathan, Raley Castle, Hautman Christopher, Sobolewski Michele, Fennessey Christine M, Hu Wei-Shau, Luke Brian, Hasson Jenna M, Niyongabo Aurelie, Capoferri Adam A, Keele Brandon F, Milush Jeff, Hoh Rebecca, Deeks Steven G, Maldarelli Frank, Hughes Stephen H, Coffin John M, Rausch Jason W, Mellors John W, Kearney Mary F
Abstract excerpt
Understanding HIV-1 persistence despite antiretroviral therapy (ART) is of paramount importance. Both single-genome sequencing (SGS) and integration site analysis (ISA) provide useful information regarding the structure of persistent HIV DNA populations; however, until recently, there was no way to link integration sites to their cognate proviral sequences. Here, we used multiple-displacement amplification (MDA)...
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