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Article

Spontaneous γH2AX foci in human dermal fibroblasts in relation to proliferation activity and aging

9 Jul 2019

Abstract excerpt

We assessed the effects of donor age on clonogenicity, proliferative potential, and spontaneous γH2AX foci in the proliferating (Ki67 +) and senescent (SA β-gal +) cultures of skin fibroblasts isolated from 34 donors of different age (23-82 years). Here, we demonstrated that neither the colony forming effectiveness of proliferating (Ki67+) fraction of the fibroblasts nor the average number of γH2AX foci of the...

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PMID: 31289256
DOI: 10.18632/aging.102067

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