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Article

Accumulation of spontaneous γH2AX foci in long-term cultured mesenchymal stromal cells

11 Dec 2016

Abstract excerpt

Expansion of mesenchymal stromal/stem cells (MSCs) used in clinical practices may be associated with accumulation of genetic instability. Understanding temporal and mechanistic aspects of this process is important for improving stem cell therapy protocols. We used γH2AX foci as a marker of a genetic instability event and quantified it in MSCs that undergone various numbers of passage (3-22). We found that γH2AX...

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PMID: 27959319
DOI: 10.18632/aging.101142

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