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Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation

1 Sept 1998

Abstract excerpt

Normal human diploid fibroblasts have a finite replicative lifespan in vitro, which has been postulated to be a cellular manifestation of aging in vivo. Several studies have shown an inverse relationship between donor age and fibroblast culture replicative lifespan; however, in all cases, the correlation was weak, and, with few exceptions, the health status of the donors was unknown. We have determined the...

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PMID: 9724752
DOI: 10.1073/pnas.95.18.10614

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