Article
A biochemical marker for differentiation is present in an in vitro aging cell system.
Biochemical and biophysical research communications - 15 Nov 1993
Rogakou E P, Sekeri-Pataryas K E
Abstract excerpt
In this study it is shown that in an in vitro aging cell system of human diploid fibroblasts the ratio of the histone variants H2A.1/H2A.2 decreases in a linear manner as a function of cumulative population doublings This ratio is known to decrease during differentiation. This finding reinforces the theory that cellular aging is a result of differentiation and programmed cell death rather than degeneration.
Topics
- Biomarkers
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Survival
- Cellular Senescence
- Electrophoresis, Gel, Two-Dimensional
- Electrophoresis, Polyacrylamide Gel
- Embryo, Mammalian
- Fibroblasts
- Genetic Variation