Differential response of human fibroblasts to the cytotoxic and mutagenic effects of UV radiation in different phases of the cell cycle.

doi:10.1016/0027-5107(85)90215-5

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Article

Differential response of human fibroblasts to the cytotoxic and mutagenic effects of UV radiation in different phases of the cell cycle.

Mutation research - 1 Jan 2000

Enninga I C, Groenendijk R T, van Zeeland A A, Simons J W

Abstract excerpt

The effects of DNA repair on UV-induced mutagenesis and cell killing in human diploid skin fibroblasts in different phases of the cell cycle were studied. The cells were synchronized in G1 by culturing at 30 degrees C. Using this synchronization method, it could be demonstrated that cells irradia...

Topics

Cell Cycle
Cell Survival
Cells, Cultured
DNA Repair
Fibroblasts
Humans
Mutation
Ultraviolet Rays

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