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Article

Restoration of histone acetylation ameliorates disease and metabolic abnormalities in a FUS mouse model

5 Jul 2019

Abstract excerpt

Dysregulation of epigenetic mechanisms is emerging as a central event in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In many models of neurodegeneration, global histone acetylation is decreased in the affected neuronal tissues. Histone acetylation is controlled by the antagonistic actions of two protein families -the histone acetyltransferases (HATs) and the histone deacetylases...

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PMID: 31277703
DOI: 10.1186/s40478-019-0750-2

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