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Article

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

4 Jul 2019

Abstract excerpt

Abstract Oncogenic mutations confer on cells the ability to propagate indefinitely, but whether oncogenes alter the cell fate of these cells is unknown. Here, we show that the transcriptional regulator PRDM16s causes oncogenic fate conversion by transforming cells fated to form platelets and erythrocytes into myeloid leukemia stem cells (LSCs). Prdm16s expression in megakaryocyte-erythroid progenitors (MEPs),...

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PMID: 31270104
DOI: 10.1182/blood.2018888255

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