Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia.

BMC cancer - 11 Nov 2015

Dong Song, Chen Jieping

Abstract excerpt

BACKGROUND: In addition to genetic and epigenetic alteration, post-translational modification of proteins plays a critical role in the initiation, progression and maturation of acute myeloid leukemia (AML). METHODS: The SUMOylation site of sPRDM16 at K568 was mutated to arginine by site-directed mutagenesis. THP-1 acute myeloid leukemia cells were transduced with a lentivirus containing wild type or K568 mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Cell Self Renewal
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Heterografts

Share to Leukemia, Myeloid, Acute

Share to Neoplastic Stem Cells

Share to Sumoylation

Source

Open in PubMed Open full text

Identifiers

PMID: 26559765
DOI: 10.1186/s12885-015-1844-2
PMCID: PMC4641379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia.PMID 26559765Read ↗

PRDM16 isoforms differentially regulate normal and leukemic hematopoiesis and inflammatory gene signatureSemantic proximity Read ↗

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cellsSemantic proximity Read ↗

Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical modelsSemantic proximity Read ↗

Sumoylation in Physiology, Pathology and TherapySemantic proximity Read ↗

Therapeutic Potential of Targeting the SUMO Pathway in CancerSemantic proximity Read ↗

Targeting WNK1 Releases Differentiation Block in Acute Myeloid LeukemiaSemantic proximity Read ↗

PRDM16 Induces Methylation of FLT3 to Promote FLT3-ITD Signaling and Leukemia Progression.Semantic proximity Read ↗

Clinical features and prognostic impact of PRDM16 expression in adult acute myeloid leukemia.Semantic proximity Read ↗

Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypesSemantic proximity Read ↗

CD56neg CD16+ cells represent a distinct mature NK cell subset with altered phenotype and are associated with adverse clinical outcome upon expansion in AML.Semantic proximity Read ↗

The post-translational modification, SUMOylation, and cancer (Review)Semantic proximity Read ↗

Prdm16 is a physiologic regulator of hematopoietic stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.