Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice.

doi:10.1016/j.exphem.2014.11.009

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Article

Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice.

Experimental hematology - 1 Mar 2015

Taylor Samuel J, Thien Christine B F, Dagger Samantha A, Duyvestyn Johanna M, Grove Carolyn S, Lee Benjamin H, Gilliland D Gary, Langdon Wallace Y

Abstract excerpt

Mutations in the Fms-like tyrosine kinase 3 (FLT3) receptor tyrosine kinase (RTK) occur frequently in acute myeloid leukemia (AML), with the most common involving internal tandem duplication (ITD) within the juxtamembrane domain. Fms-like tyrosine kinase 3-ITD mutations result in a mislocalized and constitutively activated receptor, which aberrantly phosphorylates signal transducer and activator of transcription...

Topics

Animals
Gene Expression Regulation, Neoplastic
Genetic Predisposition to Disease
Immunoblotting
Immunohistochemistry
Leukemia, Myeloid
Mice
Mutation
Proto-Oncogene Proteins c-cbl
RING Finger Domains
fms-Like Tyrosine Kinase 3

Source

Open in PubMed

Identifiers

PMID: 25534201
DOI: 10.1016/j.exphem.2014.11.009

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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