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Alzheimer’s Disease Associated Genes Ankyrin and Tau Cause Shortened Lifespan and Memory Loss in Drosophila

11 Jun 2019

Abstract excerpt

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by intracellular neurofibrillary tangles of hyperphosphorylated Tau, including the 0N4R isoform and accumulation of extracellular amyloid beta (ABeta) plaques. However less than 5% of AD cases are familial, with many addition risk factors contributing to AD including ageing, lifestyle, the environment and epigenetics. Recent...

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PMID: 31244615
DOI: 10.3389/fncel.2019.00260

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