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Article

Generation of Live Attenuated Influenza Virus by Using Codon Usage Bias

13 Aug 2015

Abstract excerpt

UNLABELLED: Seasonal influenza epidemics and occasional pandemics threaten public health worldwide. New alternative strategies for generating recombinant viruses with vaccine potential are needed. Interestingly, influenza viruses circulating in different hosts have been found to have distinct codon usage patterns, which may reflect host adaptation. We therefore hypothesized that it is possible to make a human...

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PMID: 26269186
DOI: 10.1128/jvi.01443-15

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