Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reproduction and longevity: A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart disease

25 May 2019

Abstract excerpt

BACKGROUND: According to well-established evolutionary biology theory there is a trade-off between reproduction and longevity, implying that upregulating the reproductive axis might drive major diseases. We assessed whether the central driver of reproduction gonadotropin-releasing hormone 1 (GnRH1) had a causal effect on the leading cause of global morbidity and mortality, i.e. ischemic heart disease (IHD). As a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Hypothalamic control of reproductive hormones
Share to Ovarian function and disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31198836
DOI: 10.1016/j.ssmph.2019.100411

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reproduction and longevity: A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart diseasePMID 31198836Read ↗

Reproduction and longevity A Mendelian randomization study of gonadotropin-releasing hormone and ischemic heart diseaseSemantic proximity Read ↗

Endogenous androgen exposures and ischemic heart disease, a separate sample Mendelian randomization study.Semantic proximity Read ↗

Associations of endogenous and exogenous hormonal exposures and cardiovascular disease in women – A FinnGen studySemantic proximity Read ↗

Withdrawn: Discovering Genes Essential to the Hypothalamic Regulation of Human Reproduction Using a Human Disease Model: Adjusting to Life in the "-Omics" Era.Semantic proximity Read ↗

Sex‐Specific Reproductive Factors Augment Cardiovascular Disease Risk in Women: A Mendelian Randomization StudySemantic proximity Read ↗

Chain effect of lifecourse reproductive characteristics and body fat and muscle on cardiovascular disease in women: a Mendelian randomization study.Semantic proximity Read ↗

Impaired glucose tolerance and cardiovascular risk factors in relation to infertility: a Mendelian randomization analysis in the Norwegian Mother, Father and Child Cohort StudySemantic proximity Read ↗

Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization.Semantic proximity Read ↗

Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviourSemantic proximity Read ↗

Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?Semantic proximity Read ↗

Joint and Interactive Effects of Follicle-Stimulating Hormone and Luteinizing Hormone on 10-Year Atherosclerotic Cardiovascular Disease Risk: The Mediating Role of the Triglyceride-Glucose Index in Women Undergoing Menopausal TransitionSemantic proximity Read ↗

Gonadotropin-releasing hormone receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.