Article
Gonadotropin-releasing hormone receptors.
Endocrine reviews - 1 Apr 2004
Millar Robert P, Lu Zhi-Liang, Pawson Adam J, Flanagan Colleen A, Morgan Kevin, Maudsley Stuart R
Abstract excerpt
GnRH and its analogs are used extensively for the treatment of hormone-dependent diseases and assisted reproductive techniques. They also have potential as novel contraceptives in men and women. A thorough delineation of the molecular mechanisms involved in ligand binding, receptor activation, and intracellular signal transduction is kernel to understanding disease processes and the development of specific...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- GTP-Binding Proteins
- Gonadotropin-Releasing Hormone
- Humans
- Hypogonadism
- Models, Molecular
- Molecular Sequence Data
- Molecular Structure
- Mutation