Article
Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization.
The Journal of clinical endocrinology and metabolism - 16 Jun 2022
Dam Veerle, Onland-Moret N Charlotte, Burgess Stephen, Chirlaque Maria-Dolores, Peters Sanne A E, Schuit Ewoud, Tikk Kaja, Weiderpass Elisabete, Oliver-Williams Clare, Wood Angela M, Tjønneland Anne, Dahm Christina C, Overvad Kim, Boutron-Ruault Marie-Christine, Schulze Matthias B, Trichopoulou Antonia, Ferrari Pietro, Masala Giovanna, Krogh Vittorio, Tumino Rosario, Matullo Giuseppe, Panico Salvatore, Boer Jolanda M A, Verschuren W M Monique, Waaseth Marit, Pérez Maria José Sánchez, Amiano Pilar, Imaz Liher, Moreno-Iribas Conchi, Melander Olle, Harlid Sophia, Nordendahl Maria, Wennberg Patrik, Key Timothy J, Riboli Elio, Santiuste Carmen, Kaaks Rudolf, Katzke Verena, Langenberg Claudia, Wareham Nicholas J, Schunkert Heribert, Erdmann Jeanette, Willenborg Christina, Hengstenberg Christian, Kleber Marcus E, Delgado Graciela, März Winfried, Kanoni Stavroula, Dedoussis George, Deloukas Panos, Nikpay Majid, McPherson Ruth, Scholz Markus, Teren Andrej, Butterworth Adam S, van der Schouw Yvonne T
Abstract excerpt
BACKGROUND: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. OBJECTIVES: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in...
Topics
- Aging
- Coronary Disease
- Female