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Article

Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer

1 Jun 2019

Abstract excerpt

Abstract Altered glutamine metabolism is a hallmark of cancer growth, forming the theoretical basis for development of metabolic therapies as cancer treatments. Glutaminase (GLS), a crucial enzyme involved in the regulation of glutamine metabolism, has been reported to play crucial roles in cancer development. However, the precise function of GLS in prostate cancer (PCa) remains unclear. The purpose of the...

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PMID: 31196962
DOI: 10.1042/bsr20181826

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