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Article

Glycyl-tRNA Synthetase (GARS) Expression Is Associated with Prostate Cancer Progression and Its Inhibition Decreases Migration, and Invasion In Vitro.

International journal of molecular sciences - 21 Feb 2023

Khosh Kish Ealia, Gamallat Yaser, Choudhry Muhammad, Ghosh Sunita, Seyedi Sima, Bismar Tarek A

Abstract excerpt

Glycyl-tRNA synthetase (GARS) is a potential oncogene associated with poor overall survival in various cancers. However, its role in prostate cancer (PCa) has not been investigated. Protein expression of GARS was investigated in benign, incidental, advanced, and castrate-resistant PCa (CRPC) patient samples. We also investigated the role of GARS in vitro and validated GARS clinical outcomes and its underlying...

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PMID: 36901698
DOI: 10.3390/ijms24054260
PMCID: PMC10001614

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