Article
Adult grade II diffuse astrocytomas are genetically distinct from and more aggressive than their paediatric counterparts.
Acta neuropathologica - 1 Jun 2011
Jones David T W, Mulholland Shani A, Pearson Danita M, Malley Deborah S, Openshaw Samuel W S, Lambert Sally R, Liu Lu, Bäcklund L Magnus, Ichimura Koichi, Collins V Peter
Abstract excerpt
Diffuse astrocytomas (WHO grade II) typically present as slow-growing tumours showing significant cellular differentiation, but possessing a tendency towards malignant progression. They account for ~10% of all astrocytic tumours, with a peak incidence between 30 and 40 years of age. Median survival is reported as around 6-8 years. Mutations of TP53 and IDH1 have been described as genetic hallmarks, while copy...
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