Article
The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin.
Cell reports - 24 Jun 2025
Ward Sophie, Crawford Greg, Norzawani Buang, Malactou Christina, Dutton Emma, Withnell Isabella, Woollard Kevin J, Harwood Catherine, McSorley Henry J, Ziegenhain Christoph, Lärkeryd Adrian, Sadanandam Anguraj, Strid Jessica
Abstract excerpt
Interleukin (IL)-33 is constitutively expressed in many epithelial tissues at steady state and signals through the receptor, ST2. IL-33 is released upon tissue injury and functions as an endogenous danger signal to alert the immune system to tissue damage. Here we investigate the physiological role of the IL-33/ST2 axis in skin homeostasis and cancer development. We show that the expression of IL-33...
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