Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ–Dependent Manner

20 Feb 2018

Abstract excerpt

Abstract Interleukin 33 (IL33) is an inflammatory cytokine released during necrotic cell death. The epithelium and stroma of the intestine express large amounts of IL33 and its receptor St2. IL33 is therefore continuously released during homeostatic turnover of the intestinal mucosa. Although IL33 can prevent colon cancer associated with inflammatory colitis, the contribution of IL33 signaling to sporadic colon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to IL-33, ST2, and ILC Pathways
Share to Immune Cell Function and Interaction
Share to Whipple's Disease and Interleukins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29463593
DOI: 10.1158/2326-6066.cir-17-0218

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interleukin 33 Signaling Restrains Sporadic Colon Cancer in an Interferon-γ–Dependent MannerPMID 29463593Read ↗

The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancerSemantic proximity Read ↗

Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responsesSemantic proximity Read ↗

Interleukin-33: Friend or Foe in Gastrointestinal Tract Cancers?Semantic proximity Read ↗

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis.Semantic proximity Read ↗

Dynamics of the IL-33/ST2 network in the progression of human colorectal adenoma to sporadic colorectal cancer.Semantic proximity Read ↗

IL-33 biology in cancer: An update and future perspectivesSemantic proximity Read ↗

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon CancerSemantic proximity Read ↗

Host IL11 Signaling Suppresses CD4+ T cell–Mediated Antitumor Responses to Colon Cancer in MiceSemantic proximity Read ↗

Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.Semantic proximity Read ↗

The IL-33/ST2 axis and tissue Treg maintain epithelial homeostasis and restrain cancer development in the skin.Semantic proximity Read ↗

G-CSF and G-CSFR Modulate CD4 and CD8 T Cell Responses to Promote Colon Tumor Growth and Are Potential Therapeutic Targets.Semantic proximity Read ↗

Type III TGF-β Receptor Enhances Colon Cancer Cell Migration and Anchorage-Independent GrowthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.