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A Melanoma Patient-Derived Xenograft Model

20 May 2019

Abstract excerpt

Accumulating evidence suggests that molecular and biological properties differ in melanoma cells grown in traditional two-dimensional tissue culture vessels versus in vivo in human patients. This is due to the bottleneck selection of clonal populations of melanoma cells that can robustly grow in vitro in the absence of physiological conditions. Further, responses to therapy in two-dimensional tissue cultures...

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PMID: 31157772
DOI: 10.3791/59508

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