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Article

Metastasis in an orthotopic murine model of melanoma is independent of RAS/RAF mutation.

Melanoma research - 1 Oct 2010

Rozenberg Gabriela I, Monahan Kimberly B, Torrice Chad, Bear James E, Sharpless Norman E

Abstract excerpt

Melanoma is the most lethal skin tumor in large part because of a propensity for early metastasis. Good models of this most clinically relevant feature of melanoma are lacking. Here, we report the development of an in-vivo model of metastasis that relies on orthotopic injection of green fluorescent protein-tagged lines in immunodeficient mice, serial intravital imaging of tumor progression, and quantification of...

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Source

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Identifiers

PMID: 20679910
DOI: 10.1097/CMR.0b013e328336ee17
PMCID: PMC2972650

Genes

NEDD9
TWIST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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