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Article

ATM Couples Replication Stress and Metabolic Reprogramming during Cellular Senescence

1 May 2015

Abstract excerpt

Replication stress induced by nucleotide deficiency plays an important role in cancer initiation. Replication stress in primary cells typically activates the cellular senescence tumor-suppression mechanism. Senescence bypass correlates with development of cancer, a disease characterized by metabolic reprogramming. However, the role of metabolic reprogramming in the cellular response to replication stress has been...

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PMID: 25937285
DOI: 10.1016/j.celrep.2015.04.014

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