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Article

CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer

11 Feb 2015

Abstract excerpt

Genetically activated kinases have been attractive therapeutic targets in cancer due to the relative ease of developing tumor-specific treatment strategies for them. To discover novel putative oncogenic kinases, we identified 26 genes commonly amplified and overexpressed in breast cancer and subjected them to a lentiviral shRNA cell viability screen in a panel of breast cancer cell lines. Here, we report that...

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PMID: 25670169
DOI: 10.1158/0008-5472.can-14-2443

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