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Article

Disruption of TP63-miR-27a* Feedback Loop by Mutant TP53 in Head and Neck Cancer.

Journal of the National Cancer Institute - 1 Mar 2020

Chari Nikhil S, Ivan Cristina, Le Xiandong, Li Jinzhong, Mijiti Ainiwaer, Patel Ameeta A, Osman Abdullah A, Peterson Christine B, Williams Michelle D, Pickering Curtis R, Caulin Carlos, Myers Jeffrey N, Calin George A, Lai Stephen Y

Abstract excerpt

BACKGROUND: Alterations in the epidermal growth factor receptor and PI3K pathways in head and neck squamous cell carcinomas (HNSCCs) are frequent events that promote tumor progression. Ectopic expression of the epidermal growth factor receptor-targeting microRNA (miR), miR-27a* (miR-27a-5p), inhibits tumor growth. We sought to identify mechanisms mediating repression of miR-27a* in HNSCC, which have not been...

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Share to Tumor Suppressor Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Head and Neck Neoplasms

Share to Mouth Neoplasms

Share to Neoplasm Staging

Share to Squamous Cell Carcinoma of Head and Neck

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Source

Open in PubMed Open full text

Identifiers

PMID: 31124563
DOI: 10.1093/jnci/djz097
PMCID: PMC7073912

Genes

TP53
TP63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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