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Article

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression.

Cell death & disease - 4 Apr 2013

Wang W, Cheng B, Miao L, Mei Y, Wu M

Abstract excerpt

p53 is a major tumor suppressor whose function is pivotal for protection against cancer. In over half of human cancers, p53 is inactivated due to either point mutation or loss of p53 gene. It has been well established that in addition to abrogating the tumor-suppressive function of wild-type p53, mutant p53 gains new functions and actively contributes to various stages of tumor progression. However, little is...

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Share to Cell Transformation, Neoplastic
Share to ErbB Receptors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitogen-Activated Protein Kinase 1

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Source

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Identifiers

PMID: 23559009
DOI: 10.1038/cddis.2013.97
PMCID: PMC3642368

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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