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Article

Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility

9 May 2024

Abstract excerpt

Leydig cells are essential components of testicular interstitial tissue and serve as a primary source of androgen in males. A functional deficiency in Leydig cells often causes severe reproductive disorders; however, the transcriptional programs underlying the fate decisions and steroidogenesis of these cells have not been fully defined. In this study, we report that the homeodomain transcription factor PBX1 is a...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 38724675
DOI: 10.1007/s00018-024-05249-5

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