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Article

Germline Stem Cell Activity Is Sustained by SALL4-Dependent Silencing of Distinct Tumor Suppressor Genes.

Stem cell reports - 12 Sept 2017

Chan Ai-Leen, La Hue M, Legrand Julien M D, Mäkelä Juho-Antti, Eichenlaub Michael, De Seram Mia, Ramialison Mirana, Hobbs Robin M

Abstract excerpt

Sustained spermatogenesis in adult males and fertility recovery following germ cell depletion are dependent on undifferentiated spermatogonia. We previously demonstrated a key role for the transcription factor SALL4 in spermatogonial differentiation. However, whether SALL4 has broader roles within spermatogonia remains unclear despite its ability to co-regulate genes with PLZF, a transcription factor required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28867346
DOI: 10.1016/j.stemcr.2017.08.001
PMCID: PMC5599261

Genes

SALL4
DUSP4

Provenance

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