Targeted deep sequencing of urothelial bladder cancers and associated urinary DNA : a 23‐gene panel with utility for non‐invasive diagnosis and risk stratification

Abstract excerpt

OBJECTIVES: To develop a focused panel of somatic mutations (SMs) present in the majority of urothelial bladder cancers (UBCs), to investigate the diagnostic and prognostic utility of this panel, and to compare the identification of SMs in urinary cell-pellet (cp)DNA and cell-free (cf)DNA as part of the development of a non-invasive clinical assay. PATIENTS AND METHODS: A panel of SMs was validated by targeted...

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