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Simplex Droplet Digital PCR Assays for the Detection of TERT Promoter Mutations in Urine Samples for the Non-invasive Diagnosis of Urothelial Cancer.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Zvereva Maria, Hosen Md Ismail, Forey Nathalie, Sheikh Mahdi, Kannengiesser Caroline, Ba Ibrahima, Manel Arnaud, Vian Emmanuel, Le Calvez-Kelm Florence

Abstract excerpt

Somatic mutations in the telomerase reverse transcriptase (TERT) promoter region are highly frequent in urothelial cancer (UC), and their detection in urine (cell-free DNA from the urine supernatant or DNA from exfoliated cells in the urine pellet) has demonstrated promising evidence as putative non-invasive biomarkers for UC detection and monitoring. However, detecting these tumour-derived mutations in urine...

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Share to Carcinoma, Transitional Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymerase Chain Reaction

Share to Promoter Regions, Genetic

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Share to Urinary Bladder Neoplasms

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PMID: 37410237
DOI: 10.1007/978-1-0716-3291-8_13

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