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Detection of ERBB2 Amplification by Next-Generation Sequencing Predicts HER2 Expression in Colorectal Carcinoma

27 Feb 2019

Abstract excerpt

OBJECTIVES: ERBB2 (human epidermal growth factor receptor 2 [HER2]) amplification/overexpression in colorectal carcinomas (CRCs) may predict response to HER2 inhibitors. We correlated ERBB2 amplification by next-generation sequencing (NGS) with HER2 overexpression by immunohistochemistry. METHODS: NGS was performed on specimens containing 20% or more tumor. HER2 immunohistochemistry (clone SP3) was scored...

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PMID: 31115453
DOI: 10.1093/ajcp/aqz031

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