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Estimating copy number using next-generation sequencing to determine ERBB2 amplification status

12 Mar 2021

Abstract excerpt

Assessing Erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification status in breast and gastric cancer is necessary for deciding the best therapeutic strategy. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are currently used for assessing protein levels and gene copy number (CN), respectively. The use of next-generation sequencing (NGS) to measure ERBB2 CN in breast cancer is approved by...

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PMID: 33710417
DOI: 10.1007/s12032-021-01482-1

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