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Targeted next-generation sequencing enables reliable detection of HER2 (ERBB2) status in breast cancer and provides ancillary information of clinical relevance.

Genes, chromosomes & cancer - 1 Apr 2017

Pfarr Nicole, Penzel Roland, Endris Volker, Lier Clemens, Flechtenmacher Christa, Volckmar Anna-Lena, Kirchner Martina, Budczies Jan, Leichsenring Jonas, Herpel Esther, Noske Aurelia, Weichert Wilko, Schneeweiss Andreas, Schirmacher Peter, Sinn Hans-Peter, Stenzinger Albrecht

Abstract excerpt

HER2-positive breast cancers are a heterogeneous group of tumors, which share amplification and overexpression of HER2. In routine diagnostics, the HER2 (ERBB2) status is currently assessed by immunohistochemistry (IHC) and in situ hybridization (ISH). Data on targeted next-generation sequencing (NGS) approaches that could be used to determine the HER2 status are sparse. Employing two breast cancer-related gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27792260
DOI: 10.1002/gcc.22431

Genes

ERBB2
CCND1
CDH1
EGFR
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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