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Article

Genomic profiling of colorectal cancer in large-scale Chinese patients: amplification and somatic mutations in ERBB2.

Oncology research - 1 Jan 2024

Liu Yuzhi, Bischof Evelyne, Chen Zhiqin, Zhou Jiahuan, Zhang Bei, Zhang Ding, Gao Yong, Quan Ming

Abstract excerpt

Objectives: Human epidermal growth factor receptor 2 (HER2)-targeted therapies have demonstrated potential benefits for metastatic colorectal cancer (mCRC) patients with HER2 amplification, but are not satisfactory in cases of HER2 mutant CRCs. Methods: Consequently, further elucidation of amplifications and somatic mutations in erythroblastic oncogene B-2 (ERBB2) is imperative. Comprehensive genomic profiling...

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Identifiers

PMID: 39220126
DOI: 10.32604/or.2024.047309
PMCID: PMC11361911

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