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Identification of TP53RK-Binding Protein (TPRKB) Dependency in TP53 -Deficient Cancers

20 May 2019

Abstract excerpt

Abstract Tumor protein 53 (TP53; p53) is the most frequently altered gene in human cancer. Identification of vulnerabilities imposed by TP53 alterations may enable effective therapeutic approaches. Through analyzing short hairpin RNA (shRNA) screening data, we identified TP53RK-Binding Protein (TPRKB), a poorly characterized member of the tRNA-modifying EKC/KEOPS complex, as the most significant vulnerability in...

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PMID: 31110156
DOI: 10.1158/1541-7786.mcr-19-0144

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