Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exploring the genetic driver events of eccrine poromas and porocarcinomas: a retrospective, cross-institutional study of 54 cases

15 Nov 2024

Abstract excerpt

We have comprehensively characterized the mutational landscape of eccrine poroma (EP) and eccrine porocarcinoma (EPC), uncovering novel molecular events and delineating different pathways of tumorigenesis underlying these tumours. EPs are driven largely by oncogenic fusion genes, whereas EPCs are driven largely by somatic mutations affecting various pathways, with a subset driven by fusion genes as the first...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer and Skin Lesions
Share to Soft tissue tumor case studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39546556
DOI: 10.1093/bjd/ljae447

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exploring the genetic driver events of eccrine poromas and porocarcinomas: a retrospective, cross-institutional study of 54 casesPMID 39546556Read ↗

Whole-exome sequencing identifies distinct genomic aberrations in eccrine porocarcinomas and poromasSemantic proximity Read ↗

Porocarcinomas harbor recurrent HRAS-activating mutations and tumor suppressor inactivating mutations.Semantic proximity Read ↗

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinomaSemantic proximity Read ↗

A case of YAP1 and NUTM1 rearranged porocarcinoma with corresponding immunohistochemical expression: Review of recent advances in poroma and porocarcinoma pathogenesis with potential diagnostic utilitySemantic proximity Read ↗

High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma.Semantic proximity Read ↗

Whole-exome sequencing in eccrine porocarcinoma indicates promising therapeutic strategies.Semantic proximity Read ↗

ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinomaSemantic proximity Read ↗

Acinar Cystic Transformation of the PancreasSemantic proximity Read ↗

Identification of mutations in canine oral mucosal melanomas by exome sequencing and comparison with human melanomas.Semantic proximity Read ↗

Distinct regulations driving YAP1 expression loss in poroma, porocarcinoma and RB1‐deficient skin carcinomaSemantic proximity Read ↗

PEComa: morphology and genetics of a complex tumor familySemantic proximity Read ↗

Gene Fusion-Driven Cutaneous Adnexal Neoplasms: An Updated Review Emphasizing Molecular CharacteristicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.