CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.

doi:10.1038/s41379-020-0584-2

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Article

CYLD-mutant cylindroma-like basaloid carcinoma of the anus: a genetically and morphologically distinct class of HPV-related anal carcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Dec 2020

Williams Erik A, Montesion Meagan, Sharaf Radwa, Corines James, Patel Parth J, Gillespie Brendan J, Pavlick Dean C, Sokol Ethan S, Alexander Brian M, Williams Kevin Jon, Elvin Julia A, Ross Jeffrey S, Ramkissoon Shakti H, Hemmerich Amanda C, Tse Julie Y, Mochel Mark C

Abstract excerpt

Rare reports of anal carcinoma (AC) describe histologic resemblance to cutaneous cylindroma, but mutations in the tumor suppressor CYLD, the gene responsible for familial and sporadic cylindromas, have not been systematically investigated in AC. Here, we investigate CYLD-mutant AC, focusing on molecular correlates of distinct histopathology. Comprehensive genomic profiling (hybrid-capture-based DNA sequencing)...

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Identifiers

PMID: 32461623
DOI: 10.1038/s41379-020-0584-2
PMCID: PMC7685972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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