Article
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Nature genetics - 1 Feb 2016
Okosun Jessica, Wolfson Rachel L, Wang Jun, Araf Shamzah, Wilkins Lucy, Castellano Brian M, Escudero-Ibarz Leire, Al Seraihi Ahad Fahad, Richter Julia, Bernhart Stephan H, Efeyan Alejo, Iqbal Sameena, Matthews Janet, Clear Andrew, Guerra-Assunção José Afonso, Bödör Csaba, Quentmeier Hilmar, Mansbridge Christopher, Johnson Peter, Davies Andrew, Strefford Jonathan C, Packham Graham, Barrans Sharon, Jack Andrew, Du Ming-Qing, Calaminici Maria, Lister T Andrew, Auer Rebecca, Montoto Silvia, Gribben John G, Siebert Reiner, Chelala Claude, Zoncu Roberto, Sabatini David M, Fitzgibbon Jude
Abstract excerpt
Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18) translocation and mutations affecting the epigenome. Although frequent gene mutations in key signaling pathways, including JAK-STAT, NOTCH and NF-κB, have also been defined, the spectrum of these mutations typically overlaps with that in the closely related diffuse large B cell lymphoma (DLBCL). Using a combination of discovery...
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