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Cellular stressors may alter islet hormone cell proportions by moderation of alternative splicing patterns

3 May 2019

Abstract excerpt

Changes to islet cell identity in response to type 2 diabetes (T2D) have been reported in rodent models, but are less well characterized in humans. We assessed the effects of aspects of the diabetic microenvironment on hormone staining, total gene expression, splicing regulation and the alternative splicing patterns of key genes in EndoC-βH1 human beta cells. Genes encoding islet hormones [somatostatin (SST),...

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PMID: 31098640
DOI: 10.1093/hmg/ddz094

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