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Regulation ofOCT2transcriptional repression by histone acetylation in renal cell carcinoma

15 May 2019

Abstract excerpt

Renal cell carcinoma (RCC) is a common malignant tumour affecting the urinary system, and multidrug resistance is one of the major reasons why chemotherapy for this type of cancer often fails. Previous studies have shown that loss of the human organic cation transporter OCT2 is the main factor contributing to oxaliplatin resistance in RCC, and that DNA hypermethylation and histone methylation play important roles...

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PMID: 31088315
DOI: 10.1080/15592294.2019.1615354

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