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Article

Epigenetic activation of the drug transporter OCT2 sensitizes renal cell carcinoma to oxaliplatin

20 Jul 2016

Abstract excerpt

Renal cell carcinoma (RCC) is known for its multidrug resistance. Using data obtained from the cancer transcriptome database Oncomine and the proteome database The Human Protein Atlas, we identified the repression of organic cation transporter OCT2 as a potential factor contributing to oxaliplatin resistance in RCC. By analyzing OCT2 expression in collected patient tissues and commercial tissue microarray...

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PMID: 27440728
DOI: 10.1126/scitranslmed.aaf3124

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