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Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene, by reducing open chromatin area

2022-08-25

Abstract excerpt

<title>Abstract</title> <p>IntroductionEpidemiological studies have shown that patients who recovered from acute kidney injury (AKI) may subsequently develop chronic kidney disease (CKD). AKI is primarily caused by renal hypoxia, and it causes epigenetic alterations, known as hypoxic memory. 3-Deazaneplanocin A (Dznep), an inhibitor of histone modification, suppresses renal fibrosis and the expression of tissue i...

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Literature Corpus work
2bad7a83-d64d-5859-9db1-e784a4731de2
DOI
10.21203/rs.3.rs-1961344/v1
Open publication

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