Article
Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans.
Epilepsy research - 1 Nov 2011
Kim Sae-Hoon, Lee Kyung Wha, Song Woo-Jung, Kim Sang-Heon, Jee Young-Koo, Lee Sang-Min, Kang Hye-Ryun, Park Heung-Woo, Cho Sang-Heon, Park Seong-Ho, Min Kyung-Up, Chang Yoon-Seok
Abstract excerpt
BACKGROUND: Although the US FDA recommends screening for HLA-B*1502 allele in most of Asian ancestry before initiating carbamazepine therapy, the HLA associations with carbamazepine hypersensitivity in non-Chinese Asian populations remain unclear. This study investigated the association between the HLA class I genotype and carbamazepine-induced severe cutaneous adverse reaction (SCAR) in Koreans. METHODS:...
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