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Article

Heterogeneity in refractory acute myeloid leukemia

7 May 2019

Abstract excerpt

= 131), was prognostic for overall survival (OS) and refined an established 17-gene stemness score. Refractory subpopulations have differential expression in pathways involved in cell cycle, transcription, translation, metabolism, and/or stem cell properties. Ex vivo drug sensitivity to 122 small-molecule inhibitors revealed effective group-specific targeting of pathways among these three refractory groups. Gene...

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PMID: 31064876
DOI: 10.1073/pnas.1902375116

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